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Pfizer/BioNTech Say Booster Dose Increases Protection Against Omicron In Kids Aged 5-11

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A child is administered a dose of the Pfizer-BioNTech coronavirus disease (COVID-19) pediatric vaccine, in San Jose, Costa Rica February 23, 2022. REUTERS/Mayela Lopez

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April 14 (Reuters) – A third dose of Pfizer Inc (PFE.N) and BioNTech’s (22UAy.DE) COVID vaccine produced significant protection against the Omicron variant in healthy children aged between 5 and 11 years in a trial, the companies said on Thursday.

Blood serum analysis of a few pediatric participants who received a booster dose in the study showed a 36-fold increase in Omicron neutralizing antibodies, the drugmakers said.

Neutralizing antibodies against SARS-CoV-2 wild-type strain rose six-fold following the booster shot.

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The mid-to-late stage study was testing the safety and immunogenicity of a 10 microgram booster dose in 140 healthy children aged 5 through 11 years.

Pfizer and its German partner said the data reinforces potential function of a third dose of the vaccine in maintaining high levels of protection against the virus in this age group.

The companies plan to apply for Emergency Use Authorization of a booster dose in the 5-11 age group in coming days, with additional submissions to global regulatory agencies including the European Medicines Agency to follow.

Earlier this year, the U.S. Food & Drug Administration authorized a third dose of the vaccine for children ages 12 to 15 and those aged 5 through 11 years who are immunocompromised. read more

The agency at the time said it will weigh boosters for 5 to 11 year olds after more children receive two doses.

According to the Centers for Disease Control & Prevention (CDC), about 8 million children aged between 5 and 11 in the United States are fully vaccinated.

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Reporting by Mrinalika Roy in Bengaluru; Editing by Shailesh Kuber

Our Standards: The Thomson Reuters Trust Principles.

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